Ethics of Clinical Research Involving Adults with Impaired Decision-Making Capacity
نویسندگان
چکیده
منابع مشابه
A clinical decision algorithm for hospital inpatients with impaired decision-making capacity.
BACKGROUND Impaired decision-making capacity is a frequent complication of inpatient hospitalization, with potential negative impacts on patients and the healthcare system. Studies of clinician behavior show difficulty in diagnosis and management of capacity impairment. Appropriate management of incapacitated patients may benefit safety, medical outcomes, and healthcare expenditure. OBJECTIVE...
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Two separate regulatory regimes govern research with adults who lack capacity to consent in England and Wales: the Mental Capacity Act (MCA) 2005 and the Medicines for Human Use (Clinical Trials) Regulations 2004 ("the Regulations"). A service evaluation was conducted to investigate how research ethics committees (RECs) are interpreting the requirements. With the use of a coding scheme and qual...
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BACKGROUND AND PURPOSE In stroke and other brain disorders, severely affected phenotypes often impair decision-making capacity. Severity is in part under genomic control. Therefore, scientifically valid research into genetic risk may require inclusion of such impaired individuals. U.S. Federal regulations do not detail rules governing enrollment of adults with impaired decision-making capacity ...
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Evidence-based medicine has placed a general priority on knowledge gained from clinical research for clinical decision making. However, knowledge derived from empiric, population-based research, while valued for its ability to limit bias, is not directly applicable to the care of individual patients. The gap between clinical research and individual patient care centers on the fact that empiric ...
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ژورنال
عنوان ژورنال: Bangladesh Journal of Bioethics
سال: 2016
ISSN: 2078-1458,2226-9231
DOI: 10.3329/bioethics.v7i1.29302